Syracuse, as a place name, may refer to:
Italy
- Syracuse, Sicily
- Province of Syracuse
United States
- Syracuse, New York
- East Syracuse, New York
- North Syracuse, New York
- Syracuse, Indiana
- Syracuse, Kansas
- Syracuse, Missouri
- Syracuse, Nebraska
- Syracuse, Ohio
- Syracuse, Utah
See also
- Syracuse University, in Syracuse, New York
- Syracuse Orange, the collective identity for Syracuse University athletic teams
- The Boys from Syracuse, a musical originally appearing on Broadway in 1938
- The Boys from Syracuse (film), the 1940 musical film adaptation
- The Collatz conjecture in mathematics, also known as the "Syracuse problem"
- Siege of Syracuse (214รข"212 BC), by the Romans